State of Health Podcast #6 - PUFA vs SFA in Coronary Heart Disease Meta-Analysis (Part 1)

Watch the episode on YouTube at @ https://youtu.be/XRyAGmqyQzM

On this episode of the podcast, I did another analysis of a scientific journal article about nutrition. This article from PLOS Medicine Journal (2010) suggests that replacing saturated fat (SFA) with polyunsaturated fat (PUFA) has a beneficial impact for coronary heart disease outcomes. In my review of this article, I go over the data in a detailed manner to establish how closely it supports the claims the authors are making.

In summary, the authors present 8 separate studies all of which alone show no statistical significance between control and diet intervention groups regarding heart attacks and related deaths but when the data was combined all together there was a 19% relative risk or 2% absolute risk reduction in the intervention group that was statistically significant. However, if you try to separate out the high quality evidence from the low quality evidence then there is no statistically significant risk reduction anymore. In fact, the study with the largest number of participants was suggestive of higher risk for the diet intervention group. Furthermore, if you disregard heart attacks and only look at heart attack related deaths or deaths from all causes, then again there is no statistically significant change observed between control and diet intervention groups. All taken together I don’t believe the data presented by the authors of this article supports their claim that polyunsaturated fatty acid replacement of saturated fatty acids in a diet has a beneficial effect on coronary heart disease. If that sounds interesting then this episode is for you.

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Time codes

0:00 - Intro

2:29 - Start of podcast

4:35 - Effects on Coronary Heart Disease of Increasing PUFA in Place of SFA - article intro

5:50 - Difference between SFA and PUFA

8:53 - Summary (misleading)

14:20 - Introduction

17:17 - Methods

21:46 - Results

38:53 - Discussion

41:39 - Limitations of the study

47:14 - Outro

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