Lewin brings these general principles to life by considering the history of the genetics revolution, from the discovery of the double helical structure of DNA to the sequencing of the human genome and the possibilities of gene editing today. History shows us that each period of progress in science relied on dogmas that often advanced but sometimes retarded progress, and that views of reality often changed suddenly and dramatically. Join us when Ben Lewin concludes by asking if the reductionist manifesto that has dominated biology for the past half century can continue to hold, on this installment of Leonard Lopate at Large.