Staša Stanković, PhD - Delaying Menopause, Reproductive Ageing and Genomics

What if we could delay the age of menopause?

Staša Stanković, PhD is a geneticist and bioinformatician with a PhD in Reproductive Genomics from the University of Cambridge. She focuses on deciphering genetic architecture of reproductive ageing and fertility, and their link to health outcomes in women. This work led to the discovery of genetic signals that influence the age women begin menopause and the first evidence of the ability to, through gene manipulation, extend reproductive lifespan and improve fertility in mice, thus paving the path towards first genetic test for the prediction of menopause time and next-generation therapeutics for ovary-centric disorders in humans.

(00:00) Stasa's early experiences with womanhood

(03:32) Intro to genomics in women's health

(05:33) Historical neglect in women's health research

(07:51) Delaying motherhood vs. female biology

(09:39) Redefining menopause as "reproductive ageing"

(13:54) The difference between reproductive ageing in men v. women

(14:39) Menopausal timing variation and early menopause

(16:54) How the age of menopause can help fertility planning

(19:30) How reproductive age relates to our longevity and health

(23:02) Epigenetic factors that influence menopause timing

(24:49) Mother's diet during pregnancy can influence the menopause timing of the baby

(26:46) How genomic medicine is revolutionizing reproductive ageing

(30:08) Insights from DNA analysis of 200,000 women

(39:45) How ancestry can influence menopausal timing

(42:52) Can we delay menopause today?

(46:15) Using CRISPR technology to delay menopause in mice

(48:49) The goal of delaying menopause

(59:23) Why should we "mess" with our biology?

Links:

Staša's Linkedin - https://www.linkedin.com/in/stasa-stankovic-93723a137

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